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1-Uro-/Nephrology

Guidelines

Acute Renal Failure

  • Pre-renal
    • hypovolaemia
    • hepatorenal syndrome
    • atheroembolic disease/ renal vein thrombosis
    • infection / sepsis
  • Renal
    • Toxins / medication (NSAIDs, aminoglycosides, iodinated contrast, Li, phosphate)
    • Rhabdomyolysis
    • Haemolysis
    • Multiple myeloma (: hypercalcaemia / cast nephropathy) Goldschmidt'00
    • Acute Glomerulonephritis:
      • Thin Basement Membrane Disease (AD)
      • Non-proliferative
        • Minimal change GN: 80% of NS in children: 90% cured after 3/12
        • Focal Segmental Glomerulosclerosis (FSGS): due to reflux nephropathy, Alport syndr, heroin, HIV; presents as NS
        • Membranous GN (MPGN): mixed nephrotic/nephritic picture, usu idiop, sometimes Ca, hepatitis, malaria, Penicillamine, SLE, shunt nephritis; 1/3 static, 1/3 remission, 1/3 ESRF
      • Proliferative
        • IgA nephropathy (Berger's disease): most common worldwide: macroscopic haematuria, occas NS; often young m 1-2d post URTI/GI infection; Tx: ACE-I (not steroids); variable prognosis, 20% ESRF;
          • Henoch-Schonlein purpura (HSP): systemic variant of IgA nephropathy: small vessel vasculitis
        • Post-infectious: classically post Strep pyogenes (10-14d post skin/pharyngeal infection)
        • Mesangiocapillary ?GN
        • Rapidly progressive GN (Crescentic GN)
          • AntiGBM (Goodpasture's)
          • vasculitic disorders
            • Wegener's granulomatosis
            • acute lupus nephritis
  • Post-renal
    • Medication interfering with bladder emptying
    • BPH / Prostate Cancer
    • kidney stones
    • abdominal malignancy
    • obstructed urinary catheter

Renal Registry - Standards

for patients on haemodialysis [Audit Dr Smithard, 10-Nov-08]
  • Epo prescription !00%
  • Hb>10g/dL
  • Ca:2.2-2.6mM/L
  • K:3.5-6.4mM/L
  • Chol:<5mM/L
  • Phosphate:<1.8mM/L
  • PTH:<4xULN=4x56=224
  • native fistula/graft:>80%
  • BC:20-26mM/L
  • pre-dialysis BP:<140/90
  • post-dialysis BP:<130/80
  • HbA1c:<7%
  • Ferritin>100
  • Ca-PO4-product:<4.8
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