Thrombophilia

Classification

• Acquired
• Antiphospholipid antibodies [: delay phospholipid-dependent coag tests: PTT]
• anti-cardiolipin antibodies=ACA [primary / secondary: eg SLE]; and/or
• lupus anticoagulant
• Pregnancy
• Congenital
• FVL (Factor V Leiden): 5% heterozygous
• Prothrombin mutation G20210A
• Protein C def
• Protein S def
• AT III def
• Plasminogen and fibrinolysis disorders
• PNH: Paroxysmal nocturnal haemoglobinuria