Hepatic encephalopathy
G1: altered mood/behaviour; sleep disturbances
G2: icrg drowsiness; confusion, slurred speech
G3: stupor; incoherence; restlessness, significant confusion
G4: coma
[DD: sepsis, trauma, hypoglycaemia, seizure activity]
King's College Criteria for liver transplantation
Paracetamol liver failure:
arterial pH<7.3 24h after ingestion; OR
PT>100s AND Crea>300mcM/L AND G3/4 HE
Non-Paracetamol liver failure:
PT>100s OR
3 of 5: { drug-induced liver fail | age<10 or >40 | >1wk betw onset of jaundice and HE | PT>50s | Bili>300mcM/L } |